Adam Silver lists a bunch of problems you need to solve if you opt to build a single page application.

Ironically, SPAs are harder to design and harder to build. And yet, they typically produce slow, disagreeable experiences for users. ... Javascript is never going to beat the browser at what it does best—browsing. We can still give users rich and enhanced experiences without cramming an entire site into one document. We should let the browser manage the browsing experience, and spend our time solving real user problems.